Actively Recruiting
Hybrid Ablation of Atrial Fibrillation in Heart Failure
Led by St. George's Hospital, London · Updated on 2025-11-28
120
Participants Needed
7
Research Sites
274 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
CONDITIONS
Official Title
Hybrid Ablation of Atrial Fibrillation in Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3E�3D 18 years
- Persistent or Long-standing Persistent AF
- Dilated left atrium (at least moderately dilated)
- Suitable for either procedure
- LVEF < 50%
You will not qualify if you...
- Not yet optimised from a medical or lifestyle perspective for AF or heart failure
- Unable to provide written consent
- Previous open-heart surgery
- Active infection, oesophageal ulcer stricture or oesophageal varices
- Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
- Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation
- Severe valvular heart disease
- Unstable coronary artery disease
- Uncontrolled ventricular arrhythmia
- Heart attack or stroke within the last 90 days
- Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months
- Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Ashford & St Peters Hospital NHS Trust
Chertsey, United Kingdom
Actively Recruiting
2
Epsom General Hospital
Epsom, United Kingdom
Actively Recruiting
3
Cromwell Hospital
London, United Kingdom
Active, Not Recruiting
4
Royal Surrey County Hospital
London, United Kingdom
Actively Recruiting
5
St Anthonys Hospital
London, United Kingdom
Active, Not Recruiting
6
St Georges at Kingston Hospital
London, United Kingdom
Actively Recruiting
7
St Georges University of London
London, United Kingdom
Actively Recruiting
Research Team
R
Riyaz A Kaba
CONTACT
O
Omar Ahmed
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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