Actively Recruiting
Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial
Led by University of Vermont Medical Center · Updated on 2026-02-05
103
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective single-center single-arm Phase II trial of HART for patients with metastatic cancer. The primary objective is to assess the incidence of acute GI toxicity following HART. PRO-CTCAE GI scores observed in the study patients will be compared to historical rates. Secondary outcomes include measuring changes in health-related quality of life, esophageal quality of life, toxicity, dosimetric outcomes, and pain.
CONDITIONS
Official Title
Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological confirmation of cancer with radiographic (CT, MRI or PET) evidence of metastatic disease
- Palliative radiotherapy indicated for bone or soft tissue metastases or primary targets in the thorax, abdomen, or pelvis as part of standard care
- Age 18 years or older
- Women of child-bearing potential and men must agree to use effective contraception during the study and for 90 days after therapy
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- Receiving any other investigational agents or concurrent cytotoxic chemotherapy
- Pregnant or nursing women
- Serious medical conditions that prevent safe delivery of radiation therapy as determined by the radiation oncologist
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
Research Team
N
Nataniel H Lester-Coll, MD
CONTACT
C
Christopher Anker, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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