Actively Recruiting
Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors
Led by Beijing Tiantan Hospital · Updated on 2025-01-14
882
Participants Needed
1
Research Sites
81 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess the need for hydrocortisone replacement therapy during the perioperative period for large pituitary neuroendocrine tumors. The main questions it aims to answer are: • Does hydrocortisone replacement therapy reduce the incidence of adrenal insufficiency in participants? Researchers will compare hydrocortisone to a placebo (a look-alike substance that contains no drug) to see if hydrocortisone works to reduce the incidence of adrenal insufficiency. Participants will: * Take or intravenous infusion drug hydrocortisone or a placebo every day for 2 weeks * Visit the clinic three months after surgery for checkups and tests * Keep a diary of their symptoms
CONDITIONS
Official Title
Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old
- Diagnosed with a pituitary neuroendocrine tumor suitable for endoscopic transsphenoidal surgery
- Tumor size is 2 centimeters or larger
- Intact hypothalamic pituitary adrenal axis before surgery
- Signed informed consent form by participant or legal representative
You will not qualify if you...
- History of Cushing's disease or adrenal insufficiency
- Receiving emergency or combined hormone therapy
- History of pituitary stroke
- Lack of head magnetic resonance imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing, Beijing Tiantan Hospital,Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
X
xingchao wang, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here