Actively Recruiting
HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study
Led by Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo · Updated on 2025-11-25
180
Participants Needed
1
Research Sites
224 weeks
Total Duration
On this page
Sponsors
I
Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Lead Sponsor
I
Instituto do Cancer do Estado de São Paulo
Collaborating Sponsor
AI-Summary
What this Trial Is About
The use of corticosteroids in patients with severe community pneumonia, bacterial infection which kills lots of patients around the world, reduces the mortality of this infection. However, there are no studies with this type of drug regarding hospital-acquired pneumonia. This is the first multicenter randomized trial to test hydrocortisone plus standard therapy in critical care patients with nosocomial pneumonia. This intervention is inexpensive and may improve the outcome of those patients, besides having an acceptable side effects profile.
CONDITIONS
Official Title
HYDROcortisone Versus Placebo for Severe HospItal-acquired Pneumonia in Intensive Care Patients: the HYDRO-SHIP Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Suspected or confirmed bacterial nosocomial pneumonia, including ventilator-associated pneumonia
- Stay in an intensive care unit
- Signed consent form by the patient or legal guardian
You will not qualify if you...
- Women who are pregnant, recently gave birth, or are breastfeeding
- Patients who are moribund or have no treatment options
- Patients with community-acquired pneumonia
- Patients with other types of pneumonia, including viral (COVID-19) or fungal
- Pulmonary infiltrates on chest imaging not matching bacterial pneumonia
- Patients with adrenal insufficiency
- Patients requiring corticosteroids for any condition, acute or chronic
- Patients allergic to hydrocortisone
- Patients with refractory septic shock receiving high-dose norepinephrine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital do Servidor Publico Estadual
São Paulo, Sao Paulo SP, Brazil, 04039-901
Actively Recruiting
Research Team
D
Dante Raglione, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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