Actively Recruiting
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
Led by Children's Hospital of Fudan University · Updated on 2026-03-16
60
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this proposed study is to evaluate the efficacy and safety of hydroxychloroquine (HCQ) in children's interstitial lung diseases(chILD) with genetic causes. This study is a randomized controlled clinical trial.
CONDITIONS
Official Title
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A clinical diagnosis of chILD with age <18 years
- Genetically diagnosed (e.g. SFTPC, SFTPB, ABCA3, NKX2-1, CSF2RA, CSF2RB, IARS, MARS, COPA, SLC7A7, LRBA)
- Patients have to be clinically stable with no major changes in their medication in the last 4 weeks
- No HCQ treatment in the last 12 weeks
- Signed and dated informed consent of the subject (if subject has the ability) and the representatives (of underaged children) must be available before start of any specific trial procedures
You will not qualify if you...
- Acute severe infectious exacerbations
- Known hypersensitivity to HCQ, or other ingredients of the tablets
- Proven retinopathy or maculopathy
- Renal insufficiency at screening, defined as glomerular filtration rate (GFR) < 40 mL/min/1.73 m2 in patients aged 3 to 8 weeks < 60 mL/min/1.73 m2 in patients ≥ 8 weeks of age
- Participation in other clinical trials during the present clinical trial
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Children's hospital of Fudan University
Shanghai, Shanghai Municipality, China, 201102
Actively Recruiting
Research Team
L
Liling Qian, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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