Actively Recruiting
Hydroxychloroquine in Mild Graves' Orbitopathy
Led by National Taiwan University Hospital · Updated on 2025-02-25
108
Participants Needed
2
Research Sites
249 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is aimed to investigate the effect of hydroxychloroquine in patients with mild Graves' orbitopathy (GO).
CONDITIONS
Official Title
Hydroxychloroquine in Mild Graves' Orbitopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of mild Graves' orbitopathy according to European Group on Graves' orbitopathy (EUGOGO) guidelines by endocrinologist and ophthalmologist
- No previous treatment for Graves' orbitopathy except eyedrops
- Euthyroidism with normalized free T4 and TSH for at least 2 months, or at least 6 months if radioactive iodine was used for hyperthyroidism
You will not qualify if you...
- Moderate-to-severe or sight-threatening Graves' orbitopathy according to EUGOGO guidelines diagnosed by endocrinologist and ophthalmologist
- Pregnancy
- Drug or alcohol abuse
- Unable to comply with the study protocol or provide informed consent
- Use of hydroxychloroquine or systemic steroids within 3 months prior to enrollment
- History of hydroxychloroquine side effects or retinopathy
- Kidney dysfunction (eGFR < 60 ml/min)
- Liver dysfunction (AST or ALT more than twice the upper limit)
- Anemia (hemoglobin less than 10 g/dl)
- Neutropenia (absolute neutrophil count less than 100/uL)
- Thrombocytopenia (platelet count less than 150,000/uL)
- Glucose-6-phosphate dehydrogenase deficiency
- Porphyria cutanea tarda
- Allergy to 4-aminoquinoline drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
National Taiwan University Hospital, Hsin-Chu branch
Hsinchu, Taiwan
Actively Recruiting
2
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
S
Shyang-Rong Shih
CONTACT
H
Hung-Yuan Li
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here