Actively Recruiting

Age: 18Years - 60Years
All Genders
Healthy Volunteers
NCT06978803

HYEEG Discourse in Psychosis: A Neurobehavioural Study

Led by Douglas Mental Health University Institute · Updated on 2025-05-18

110

Participants Needed

1

Research Sites

154 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify measurable markers of disorganized communication and link them to clinical symptoms and social functioning. Key Research Questions: How do neural and behavioural synchrony contribute to social impairments in schizophrenia? What roles do interbrain synchrony, motor imitation, reaction time, and verbal coherence play in disorganized communication? Participants will: 1. Engage in structured and semi-structured real-time social interactions while undergoing dual-brain electroencephalogram (EEG) hyperscanning to measure neural and behavioural activity. 2. Perform nonverbal tasks such as motor imitation and reaction time assessments to investigate coordination and behavioural synchrony patterns. 3. Participate in a clinical interview that evaluates verbal production, thought coherence, and speech organization. By combining these assessments, the study aims to advance our understanding of how social and communication impairments manifest in schizophrenia. The findings will contribute to developing improved diagnostic tools and targeted interventions, ultimately supporting patients in achieving better social functioning and quality of life.

CONDITIONS

Official Title

HYEEG Discourse in Psychosis: A Neurobehavioural Study

Who Can Participate

Age: 18Years - 60Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • English or French-speaking participants matched as dyads
  • Age between 18 and 60 years
  • Diagnosed with schizophrenia or schizoaffective disorder by a psychiatrist according to DSM-5 criteria
  • Illness onset less than 5 years ago based on starting antipsychotic treatment
Not Eligible

You will not qualify if you...

  • Primary diagnosis of alcohol or drug addiction (co-morbid substance abuse with psychotic disorder allowed)
  • Severe medical disorder explaining psychotic symptoms
  • Past or current primary neurological disorder affecting speech
  • IQ below 70 or concurrent pervasive developmental disorder such as autism

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Douglas Mental Health University Institute

Montreal, Quebec, Canada, H4H 1R3

Actively Recruiting

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Research Team

E

Emmanuel Olarewaju, PhD Candidate

CONTACT

L

Lena Palaniyappan, MD, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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