Actively Recruiting
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Led by University of Virginia · Updated on 2020-11-04
30
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
CONDITIONS
Official Title
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects must have a diagnosis of COPD
- Subjects must be at their clinical baseline on the day of imaging
- Subjects must be clinically stable in order to participate
- COPD subjects will be categorized according to the GOLD criteria
- Subjects must be current or former smokers
- Subjects must have a smoking history of at least 10 pack years
You will not qualify if you...
- Diagnosis of asthma
- Continuous oxygen use at home
- Blood oxygen saturation less than 92% as measured by pulse oximetry on the day of imaging
- FEV1 percent predicted less than 25%
- Pregnancy or lactation
- Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
- Subjects with any implanted device that cannot be verified as MRI compliant
- Chest circumference greater than approximately 42 inches (coil size limit)
- History of congenital cardiac disease, chronic renal failure, or cirrhosis
- Inability to understand simple instructions or to hold still for about 10 seconds
- History of respiratory infection within 2 weeks prior to the MR scan
- History of myocardial infarction, stroke, or poorly controlled hypertension
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Virginia Health System
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
S
Sarah Struchen, RN
CONTACT
R
Roselove Nunoo-Asare, RT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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