Actively Recruiting
Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis
Led by Guangdong Provincial People's Hospital · Updated on 2025-02-12
380
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
Sponsors
G
Guangdong Provincial People's Hospital
Lead Sponsor
F
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis. Hyperbaric oxygen can improve the tissue after radiation by promoting the function of vascular endothelial cells and fibroblasts, and reducing the secretion of inflammatory factors, thereby inhibiting the process of fibrosis and fiber atrophy after radiotherapy, and promoting tissue repair. Therefore, it has the potential value of treating chronic radiation injury. We aim to investigate whether hyperbaric oxygen treatment can reduce the incidence of radiation pneumonia and improve patients' quality of life, and to evaluate its safety and the impact on the patients' long-term survival outcomes.
CONDITIONS
Official Title
Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Volunteer to participate and sign informed consent.
- Diagnosed with breast cancer and completed radical surgery followed by chemotherapy and radiotherapy.
- No simple neck lymph node recurrence or distant metastases.
- No secondary malignant tumors.
- Age between 18 and 70 years, male or female.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
- Expected survival of at least 2 years.
- No acute radiation lung injury on chest CT before and after radiotherapy.
You will not qualify if you...
- Contraindications to hyperbaric oxygen therapy including severe lung diseases, past ear surgery, middle ear or eye diseases.
- Previous hyperbaric oxygen therapy.
- Existing radiation pneumonia at enrollment or before therapy.
- Pregnant or breastfeeding women.
- Incomplete breast cancer treatment due to disease progression or intolerable side effects.
- Need for mechanical ventilation support.
- Unable to follow or understand simple commands.
- Disorientation or mental disorders.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510080
Actively Recruiting
Research Team
K
Kun Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
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