Actively Recruiting
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Led by University of Calgary · Updated on 2026-05-07
26
Participants Needed
1
Research Sites
464 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem. Blood gases, like carbon dioxide (CO2), have an important effect on sympathetic activation. The purpose of this research study is to determine if higher CO2 levels have any effect in lowering heart rate and reducing POTS symptoms when upright/standing. The investigators are also searching for the ideal CO2 concentration to achieve the most effective response
CONDITIONS
Official Title
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician diagnosis of Postural Tachycardia Syndrome (POTS)
- Age 18-60 years
- Male and Female
- Non - smokers
- Able and willing to provide informed consent
- Ability to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB
You will not qualify if you...
- Overt cause for postural tachycardia, such as acute dehydration
- Participants with somatization or severe anxiety symptoms
- Pregnant
- Inability to tolerate mask for the duration of the study
- Need for portable oxygen at rest or with exercise
- Chronic heart failure or severe lung disease causing inability to climb one flight of stairs due to shortness of breath
- Any other factors that would prevent completing the study, including poor compliance in previous studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4Z6
Actively Recruiting
Research Team
S
Shaun Ranada, BSc
CONTACT
R
Rasha Hamza, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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