Actively Recruiting
Hyperfractionated Dual Equivalent Fractionated Radiation Therapy
Led by Yale University · Updated on 2025-11-04
10
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
A
American Cancer Society, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates the feasibility and safety of a novel method for comparing the effectiveness of hypofractionated versus hyperfractionated radiation therapy in participants with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) undergoing T-cell redirection therapies (CAR T-cell therapy or bispecific antibodies).
CONDITIONS
Official Title
Hyperfractionated Dual Equivalent Fractionated Radiation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form.
- Willingness to comply with all study procedures and availability for the study duration.
- Adults aged 18 years or older.
- Histologically confirmed R/R DLBCL with tumor size 5 cm and plan for CAR T or bispecific antibody therapy.
- ECOG performance status between 0 and 3.
- Ability to attend twice daily (Monday to Friday) fractionated radiation therapy without contraindications.
- Women of childbearing potential must have negative pregnancy tests at screening and radiation planning and agree to use effective pregnancy prevention methods during the study.
You will not qualify if you...
- Current pregnancy or breastfeeding.
- Prior radiation exposure for research purposes within the past year that exceeds FDA limits.
- Inability to safely receive FDG PET tracer.
- Any condition posing significant risk, interfering with study participation, or affecting study data interpretation.
- Inability to participate in twice daily radiotherapy or clinical contraindications to radiation therapy.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
Research Team
S
Stephanie Ladd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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