Actively Recruiting
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Led by Mario Castro, MD, MPH · Updated on 2026-05-06
260
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of hyperpolarized (HP) 129Xe gas MRI to assess lung function regionally in both healthy volunteers and people with pulmonary diseases. This open-label study includes about 160 participants with diagnosed lung conditions and about 100 healthy adults aged 18 to 80 years. The goal is to develop and examine the usefulness of this imaging method for understanding pulmonary function. Participants will undergo imaging on a single outpatient visit, where they will inhale up to four 1-liter doses of HP 129Xe gas plus one calibration dose during MRI scans. The study also collects standard anatomical MR images of the lungs and vasculature using different breath-hold techniques. All imaging is performed at one center using specialized equipment to capture detailed lung function data. During the study visit, participants will be asked to hold their breath for 15 to 16 seconds while inhaling the xenon gas for MRI scanning. Researchers will monitor lung function using measures like the red blood cell to barrier ratio, apparent diffusion coefficient, and ventilation defect percentage. The study includes safety screening for MRI compatibility and breath-holding ability. Participation involves a single visit focused on imaging and lung function assessments.
CONDITIONS
Brief Title
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Healthy volunteers with no diagnosed pulmonary conditions
- Subjects with a physician-diagnosed pulmonary dysfunction
- No acute worsening of pulmonary function in the past 30 days for subjects with lung disease
- Ability to read and understand English or Spanish
You will not qualify if you...
- MRI contraindicated based on MRI screening questionnaire
- Pregnant or lactating individuals
- Unable to fit into 129Xe vest coil used for MRI
- Unable to hold breath for 15-16 seconds
- Unlikely to comply with instructions during imaging
- Oxygen saturation less than 88% on room air or supplemental oxygen
- Cognitive deficits preventing consent
- Institutionalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo MRI scanning involving inhalation of hyperpolarized xenon gas to assess lung function and collect anatomical images.
1 imaging visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
Research Team
C
Cristal Monge
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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