Use of Hyperpolarized 129Xe MRI to Assess Lung Function in Adults With and Without Pulmonary Disease

What this Trial Is About

Researchers are evaluating the use of hyperpolarized HP 129Xe gas MRI to assess lung function regionally in both healthy volunteers and people with pulmonary diseases. This open-label study includes about 160 participants with diagnosed lung conditions and about 100 healthy adults aged 18 to 80 years. The goal is to develop and examine the usefulness of this imaging method for understanding pulmonary function. Participants will undergo imaging on a single outpatient visit, where they will inhale up to four 1-liter doses of HP 129Xe gas plus one calibration dose during MRI scans. The study also collects standard anatomical MR images of the lungs and vasculature using different breath-hold techniques. All imaging is performed at one center using specialized equipment to capture detailed lung function data. During the study visit, participants will be asked to hold their breath for 15 to 16 seconds while inhaling the xenon gas for MRI scanning. Researchers will monitor lung function using measures like the red blood cell to barrier ratio, apparent diffusion coefficient, and ventilation defect percentage. The study includes safety screening for MRI compatibility and breath-holding ability. Participation involves a single visit focused on imaging and lung function assessments.

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease