Actively Recruiting
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
Led by Bastiaan Driehuys · Updated on 2026-01-16
445
Participants Needed
1
Research Sites
1039 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC), and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such imaging of 129Xe gas transfer is expected to be uniquely sensitive to pathologies affecting gas exchange (fibrosis, emphysema, pulmonary hypertension) and provide new insights regarding the normal resting heterogeneity of pulmonary gas exchange.
CONDITIONS
Official Title
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For healthy controls: no diagnosed lung conditions
- For healthy controls: no smoking within the past 5 years
- For healthy controls: smoking history of 5 pack-years or less
- For lung disease subjects: diagnosed pulmonary dysfunction by a doctor
- For lung disease subjects: no recent worsening of lung function within 30 days
You will not qualify if you...
- Under 18 years old
- MRI contraindicated based on screening questionnaire
- Pregnant or breastfeeding
- Respiratory infection within 30 days before MRI
- Received investigational drugs (except 129Xe) within 30 days
- Any known heart rhythm problems
- Does not fit into the 129Xe MRI vest coil
- Unable to hold breath for 15 seconds
- Unlikely to follow instructions during imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
J
Jennifer Korzekwinski
CONTACT
C
Cody Blanton
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
0
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