Actively Recruiting
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
Led by University of Maryland, Baltimore · Updated on 2025-05-11
15
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived metrics in TBI patients with healthy subjects as well as Subarachnoid hemorrhage (SAH) patients to better understand if metabolic Magnetic resonance imaging scan (MRI) can improve our ability to diagnose a TBI. The FDA is allowing the use of hyperpolarized \[1-13C\] pyruvate (HP 13C-pyruvate) in this study. Up to 15 patients (5 with TBI, 5 with SAH, and 5 healthy volunteers) may take part in this study at the University of Maryland, Baltimore (UMB).
CONDITIONS
Official Title
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of acute head injury with or suspected non-penetrating acute TBI
- Suitable to undergo contrast-enhanced MRI
- Negative serum pregnancy test
You will not qualify if you...
- Inability to undergo MRI scan
- Inability to receive IV MRI contrast agents due to severe reaction or kidney problems
- Positive pregnancy test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Maryland Baltimore
Baltimore, Maryland, United States, 21201
Actively Recruiting
Research Team
R
Rosy Linda Njonkou Tchoquessi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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