Study of Hyperpolarized 13C-Pyruvate MRI to Detect Early Brain Metabolism Changes After Traumatic Brain Injury and Subarachnoid Hemorrhage

What this Trial Is About

Researchers are evaluating the use of hyperpolarized metabolic magnetic resonance imaging MRI to study early brain metabolism changes in people who have had a head injury or suspected non-penetrating traumatic brain injury TBI. This study aims to compare MRI-derived metabolic measures in TBI patients with those in healthy volunteers and patients with subarachnoid hemorrhage SAH to see if this imaging method can improve diagnosis of TBI. The study is in a Phase 1 stage and uses hyperpolarized 1-13C pyruvate, allowed by the FDA for this purpose. Participants will undergo metabolic MRI scans involving an injection of hyperpolarized 13C-pyruvate, which is studied as a diagnostic agent to visualize metabolism in the brain. The study includes three groups patients with TBI, patients with SAH, and healthy volunteers. Each participant will have the metabolic MRI performed to assess brain metabolism in their respective groups. During the study, researchers will measure how pyruvate converts to lactate and bicarbonate in the brain within two years after enrollment. They will also correlate these metabolic measures with clinical and neuropsychological evaluations. Up to 15 participants are expected, including 5 with TBI, 5 with SAH, and 5 healthy volunteers. The study includes safety monitoring and follow-up assessments to better understand brain metabolism changes after injury.

Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury