Actively Recruiting

Phase 1
Age: 19Years +
All Genders
NCT03739411

Hyperpolarized Imaging in Diagnosing Participants With Glioma

Led by Susan Chang · Updated on 2026-03-27

140

Participants Needed

1

Research Sites

651 weeks

Total Duration

On this page

Sponsors

S

Susan Chang

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This pilot trial studies the side effects of hyperpolarized carbon C 13 pyruvate magnetic resonance imaging (MRI) in diagnosing participants with glioma. Diagnostic procedures, such as hyperpolarized carbon C 13 pyruvate MRI, may help find and diagnose glioma.

CONDITIONS

Official Title

Hyperpolarized Imaging in Diagnosing Participants With Glioma

Who Can Participate

Age: 19Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologically proven glioma with evidence of evaluable disease based on prior MRI (Cohort 1)
  • Histologically proven glioma scheduled to undergo treatment (Cohort 2)
  • Age over 18 years
  • Life expectancy greater than 12 weeks
  • Karnofsky performance status of 60 or higher
  • Adequate kidney function with creatinine below 1.5 mg/dL tested within 60 days prior to imaging
  • No significant uncontrolled medical illnesses that could affect study participation or imaging
  • No New York Heart Association Grade II or greater congestive heart failure
  • No myocardial infarction or unstable angina within 12 months prior to enrollment
  • Males and females of all races eligible
  • Ability to provide informed consent and authorization for health information release
  • Not known to be HIV-positive
  • No history of other cancers except non-melanoma skin cancer or cervical carcinoma in-situ unless in remission and off therapy for at least 3 years
  • Not pregnant or breastfeeding; women of childbearing potential must have a negative pregnancy test within 14 days of imaging
  • Effective contraception required for participants of childbearing potential
Not Eligible

You will not qualify if you...

  • Unable to comply with study or follow-up procedures

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of California, San Francisco

San Francisco, California, United States, 94143

Actively Recruiting

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Research Team

W

Wendy Ma

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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