Actively Recruiting
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
Led by M.D. Anderson Cancer Center · Updated on 2026-05-05
25
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop bronchiolitis obliterans syndrome (BOS) or BOS stage 0p (pulmonary impairment not meeting the definition for BOS, defined below) and controls with chronic graft-versus-host disease (cGVHD). The primary objective of the study is to correlate 129-Xenon measures of ventilation, gas exchange, and pulmonary circulation with spirometric and quantitative CT measurements. A secondary objective is to determine whether measurement of 129-Xe MRI characteristics in patients with BOS stage 0p can predict BOS progression 6 months after enrollment.
CONDITIONS
Official Title
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Allo-HCT recipients aged 18 years or older with BOS, BOS 0p, or chronic graft-versus-host disease without lung impairment
- Healthy adults aged 18 years or older with no medical issues for technical calibration
- Study team members without prior lung disease may volunteer as healthy controls (data excluded from analysis)
You will not qualify if you...
- Unable to follow up at MD Anderson for routine care
- Unable or unwilling to give informed consent
- Relapsed disease or life expectancy less than 6 months at enrollment
- Severe claustrophobia preventing MRI
- Active pulmonary infection
- Pregnant women
AI-Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
A
Ajay Sheshadri
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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