Actively Recruiting
Hyperpolarized Xenon-129 MR Imaging of the Lung
Led by University of Virginia · Updated on 2020-12-10
24
Participants Needed
1
Research Sites
264 weeks
Total Duration
On this page
Sponsors
U
University of Virginia
Lead Sponsor
D
Duke University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy young adults. Therefore, establishing the health effects of e-cigarettes in humans is of paramount importance to guide medical and regulatory decision making. Its widespread use and immense popularity among teenagers and young adults have caused major concern given potentially significant addictive and detrimental long-term health effects.
CONDITIONS
Official Title
Hyperpolarized Xenon-129 MR Imaging of the Lung
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects 21-30 years of age
- At baseline health with no recent illnesses or medical conditions that would preclude enrollment as assessed by the Principal Investigator
- Ability to understand a written informed consent form and comply with the requirements of the study
- E-cigarette use for more than 6 months preceding enrollment and less than a 5 pack year smoking history (e-cigarette users) OR less than a 5 pack year smoking history (non-smoker group)
- No diagnosis of any lung disease (pre-bronchodilator FEV1/FVC normal on screening day defined by > 95thCI of NHANES III, ATS/ERS guideline)
You will not qualify if you...
- History of any lung disease
- Control (non-smoking) group: History of illegal drug use by inhalation
- History of CNS disease including stroke and dementia, end-stage liver disease, coronary artery disease, renal failure
- Acute infection of any kind in the previous 6 weeks
- Pregnancy or possibility of pregnancy
- Anemia
- Inability to undergo MR imaging based on standard clinical MRI criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Snyder Building 480 Ray C. Hunt Drive
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
R
Roselove Asare
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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