Actively Recruiting
Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Led by King's College London · Updated on 2025-12-02
200
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
Sponsors
K
King's College London
Lead Sponsor
G
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is: What is the prevalence of hypertension in a population sample of adolescents with ADPKD? Participants will have the following measurements performed: * Height and weight. * Blood pressure. * Non-invasive measurement of arterial stiffness. * Cardiac and renal MRI. * Blood sample. * Genetic testing.
CONDITIONS
Official Title
Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 12 to 17 years at the time of consent
- Able to tolerate key study tests including blood pressure measurement, MRI, and blood tests
- Has a parent with a confirmed diagnosis of ADPKD
- Parent (if child is under 16) or both parent and young person (if 16 or older) consent to genetic testing and understand its implications
You will not qualify if you...
- Age 18 years or older at the time of study entry
- Unable to tolerate key study tests
- Presence of other medical conditions that affect interpretation of results, such as congenital heart defects or known TSC-PKD1 mutations
- Unwilling to undergo genetic testing for ADPKD
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Evelina London Children's Hospital
London, United Kingdom, SE1 7EH
Actively Recruiting
Research Team
B
Benjamin Boxer, PhD
CONTACT
L
Louise Keehn, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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