Actively Recruiting

Phase Not Applicable
Age: 35Years +
All Genders
NCT06952348

HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking

Led by Karolinska Institutet · Updated on 2025-12-08

450

Participants Needed

4

Research Sites

178 weeks

Total Duration

On this page

Sponsors

K

Karolinska Institutet

Lead Sponsor

S

Stockholm South General Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

This clinical trial investigates whether incorporating stair walking into daily routines improves physical health in adults at risk of lifestyle-related conditions such as hypertension, type 2 diabetes, and cardiovascular disease. Participants will be randomized into three groups: (1) stair walking combined with brisk walking, (2) brisk walking alone, and (3) a control group receiving standard lifestyle advice without specific exercise instructions, stratified by age (\<65 y/o, v \>=65) and site. The primary objective is to assess whether the combination of stair and brisk walking leads to greater reductions in systolic blood pressure compared to brisk walking alone or standard care. Secondary outcomes include changes in cardiometabolic risk factors. Participants in the stair walking group will be instructed to climb ≥250 steps per day (\~5.5 minutes/day or \~37.5 minutes/week), or complete an equivalent elevation via inclined slopes, along with ≥75 minutes of brisk walking per week. Those in the brisk walking group will walk ≥150 minutes per week. The control group will receive general lifestyle advice but no tailored physical activity goals or feedback. Participants in both active groups will aim to double their baseline activity levels. Physical activity will be continuously monitored using wearable devices. The active groups will receive personalized feedback and motivational support throughout the 6-month intervention period. If effective, this study may offer a simple, scalable, and low-cost intervention model for use in clinical and public health settings, emphasizing personalized goals, remote monitoring, and behavioral support.

CONDITIONS

Official Title

HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking

Who Can Participate

Age: 35Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Men and women aged 35 years or older with increased cardiometabolic risk
  • Clinically confirmed hypertension, with or without antihypertensive treatment, documented in Electronic Health Record
  • Overweight or obesity with BMI between 27 and 40
  • Physically inactive lifestyle defined by light intensity or inactive category on Stanford Brief Activity Survey or Swedish National Board of Health and Welfare Lifestyle Questionnaire
Not Eligible

You will not qualify if you...

  • Severe, symptomatic aortic stenosis
  • Acute pulmonary embolism, myocarditis, pericarditis, or systemic infection
  • Suspected or known aortic dissection
  • Severe hypertension (Grade 3: SBP >180 mmHg or DBP >110 mmHg), regardless of symptoms
  • Unstable coronary artery disease or recent myocardial infarction within 8 weeks
  • Symptomatic, uncontrolled arrhythmia or heart failure
  • Implanted pacemaker or ICD
  • Pregnancy
  • Smartphone incompatible with required app (iOS <16 or Android OS <10)
  • Inability to understand Swedish or English
  • Any condition interfering with protocol compliance (e.g., severe mental illness or cognitive impairment)
  • Inability to walk stairs

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 4 locations

1

Karolinska Universitetssjukhuset Huddinge

Stockholm, Sweden

Not Yet Recruiting

2

Liljeholmen Primary Care Center

Stockholm, Sweden

Actively Recruiting

3

Södersjukhuset

Stockholm, Sweden

Not Yet Recruiting

4

Södertälje sjukhus

Stockholm, Sweden

Not Yet Recruiting

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Research Team

C

Carl Johan Sundberg

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking | DecenTrialz