Actively Recruiting
Hypertonic Saline for MAC
Led by Oregon Health and Science University · Updated on 2025-08-15
50
Participants Needed
3
Research Sites
241 weeks
Total Duration
On this page
Sponsors
O
Oregon Health and Science University
Lead Sponsor
N
NTM Info & Research, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The MAC-HS study is a testing whether hypertonic saline helps improve symptoms and clearance of mycobacteria in patients with M. avium complex lung infections.
CONDITIONS
Official Title
Hypertonic Saline for MAC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 2 positive MAC sputum cultures in the last 12 months with at least one acid-fast bacilli positive sputum obtained within 12 weeks before randomization
- Meet American Thoracic Society/Infectious Disease Society of America 2007 pulmonary clinical disease criteria
- Age 18 years or older
- Diagnosis of bronchiectasis and/or bronchiectatic findings on chest CT report
- Ability to provide informed consent
You will not qualify if you...
- Unable or unwilling to provide consent or comply with the study protocol
- Cavitary nontuberculous mycobacterial disease
- Use of bedaquiline or any ATS/IDSA recommended MAC treatment drugs (macrolide, ethambutol, rifampin) within the past 6 months
- Diagnosis of HIV infection
- Diagnosis of cystic fibrosis
- Active pulmonary tuberculosis, fungal, or nocardial infection requiring treatment at screening
- Use of chronic systemic corticosteroids at doses of 15 mg/day or more for over 3 months
- Prior lung or other solid organ transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
NYU Langone Health
New York, New York, United States, 10016
Active, Not Recruiting
2
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
3
University Health Network
Toronto, Ontario, Canada, ON M5G
Actively Recruiting
Research Team
D
Daniel Bouchat
CONTACT
A
Alyssa Schroeder
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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