Actively Recruiting
Hypofractionated Online Adaptive Radiotherapy of Breast Cancer
Led by Peking Union Medical College Hospital · Updated on 2026-03-20
40
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to explore the application of online adaptive radiotherapy in patients who receive moderate hypofractionated or ultrafractionated radiotherapy after breast cancer surgery. The main questions it aims to answer are: * Can online adaptive radiotherapy improve the accuracy of dose delivery? * In patients undergoing online adaptive radiotherapy, how are the treatment-related toxicities and tumor control outcomes? Participants will Receive moderate hypofractionated radiotherapy using online adaptive radiotherapy, a dose of 43.5Gy in 15 fractions or receive ultrafractionated radiotherapy using online adaptive radiotherapy, a dose of 26Gy in 5 fractions.
CONDITIONS
Official Title
Hypofractionated Online Adaptive Radiotherapy of Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, aged 6535 years and under 70 years
- ECOG performance status score of 0 to 2
- Have undergone breast-conserving surgery or modified radical mastectomy, with or without sentinel lymph node biopsy or axillary lymph node dissection
- Pathologically confirmed primary breast cancer diagnosis
- For patients without neoadjuvant therapy: pathological stage pT0-2N0-1; for those with neoadjuvant therapy: staged ypT0-2N0-1
- Indicated for and planned to undergo postoperative adjuvant radiotherapy
- Able to cooperate with and tolerate the treatment
You will not qualify if you...
- Pathologically confirmed metastasis in supraclavicular or infraclavicular lymph nodes, or distant metastasis
- History of radiotherapy to the neck or chest
- Contraindications or intolerance to radiation therapy, including pregnancy or lactation; severe heart, lung, kidney, liver, or other vital organ impairment; severe infection or blood abnormalities; brachial plexus nerve injury on the affected side; active connective tissue diseases
- History of other malignant tumors
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, China
Actively Recruiting
Research Team
X
Xiaorong Hou, MD
CONTACT
X
Xiaorong Hou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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