Actively Recruiting
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study
Led by Emory University · Updated on 2026-02-17
70
Participants Needed
1
Research Sites
614 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells. A shorter duration of radiation treatment may avoid some of the delayed side effects of radiation while providing a more convenient treatment and reducing costs.
CONDITIONS
Official Title
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with benign intracranial or nerve sheath tumor, including meningiomas, pituitary adenomas, schwannomas, or WHO grade 2-3 meningiomas
- Recommended to receive proton or photon fractionated radiation therapy
- Signed informed consent to participate
You will not qualify if you...
- Pregnant females are excluded
- Female participants who can have children must have a negative pregnancy test prior to therapy and agree to use effective contraception or abstain during the study
- Prior radiation therapy overlapping the current treatment area
- Inability to undergo magnetic resonance imaging (MRI)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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