Actively Recruiting
Hypofractionated Radiation Therapy for Merkel Cell Carcinoma
Led by M.D. Anderson Cancer Center · Updated on 2026-01-14
52
Participants Needed
1
Research Sites
350 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II trial tests whether hypofractionated radiation works to treat patients with Merkel cell carcinoma. Radiation therapy uses high energy radio waves to kill cancer cells and shrink tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may be more convenient for patients and less immunosuppressive.
CONDITIONS
Official Title
Hypofractionated Radiation Therapy for Merkel Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have histologically or cytologically confirmed Merkel cell carcinoma.
- No evidence of distant metastasis by clinical exam and imaging.
- Surgical removal of the primary tumor within 4 months before starting radiation therapy if planned for primary tumor radiation.
- For nodal radiation, prior positive sentinel lymph node biopsy with any nodal involvement within 4 months without completion nodal dissection, or lymph node dissection within 4 months with high-risk nodal disease.
- Immunotherapy is allowed before, during, or after radiation therapy.
- Age 18 years or older.
- ECOG performance status of 3 or less.
- Patients with prior or concurrent malignancies that do not interfere with safety or efficacy assessment are eligible.
- Women of childbearing potential and men must agree to use effective contraception during the study and for specified periods.
- Ability to understand and willing to sign informed consent.
You will not qualify if you...
- Prior radiation therapy to the planned treatment site that would require re-irradiation.
- Presence of distant metastases.
- Pregnant women.
- Patients younger than 18 years of age.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
Devarati Mitra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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