Actively Recruiting
Hypofractionated Radiosurgery for Localised Prostate Cancer (HYPOSTAT-III)
Led by University Hospital Schleswig-Holstein · Updated on 2026-04-29
175
Participants Needed
6
Research Sites
211 weeks
Total Duration
On this page
Sponsors
U
University Hospital Schleswig-Holstein
Lead Sponsor
U
University of Luebeck
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hypofractionated radiosurgery with 5 fractions is considered standard of care for localized prostate cancer. The investigators initiated this multicenter phase II prospective trial to analyse feasibility (toxicity) of hypofractionated radiosurgery with 3 fractions in patients with localised prostate cancer under the hypothesis that the ratio of patients with late GU and GI toxicity ≥ grade 2 after 1 year amounts to 8.4% and 1.3% and is significant lower than 16.4% and 5.7% currently.
CONDITIONS
Official Title
Hypofractionated Radiosurgery for Localised Prostate Cancer (HYPOSTAT-III)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Localised, histopathologically confirmed Prostate Cancer (cT1-T2c N0 M0)
- Gleason-grade �3d7, ISUP Grade Group 1-3
- Guideline-based staging
- Age �3e= 18 years
- PSA < 20 ng/ml
- Volume of the prostate < 80 cm�b3
- IPSS-Score �3c= 12
- Written informed consent
You will not qualify if you...
- History of prior pelvic radiotherapy
- Previous transurethral resection, laser enucleation or prostate ablation
- Contraindication to MRI or Fiducial marker implantation (e.g. gold allergy)
- Relevant comorbidity thought to adversely affect treatment compliance
- Legal incapacity or lack of informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Saphir Radiosurgery Center Frankfurt am Main
Frankfurt am Main, Hesse, Germany, 60528
Actively Recruiting
2
University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany, 60528
Suspended
3
European Radiosurgery Center Munich
Munich, Hesse, Germany, 81377
Actively Recruiting
4
Saphir Radiosurgery Center Norther Germany
Kiel, Schleswig-Holstein, Germany, 24105
Active, Not Recruiting
5
University Medical Center Schleswig-Holstein
Kiel, Schleswig-Holstein, Germany, 24105
Actively Recruiting
6
CyberKnife Centrum Mitteldeutschland
Erfurt, Thuringia, Germany, 99089
Actively Recruiting
Research Team
O
Oliver Blanck, PhD
CONTACT
F
Frauke Walther-Clausnizer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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