Study Comparing Two Shorter Radiation Therapy Plans Followed by Surgery for Soft Tissue Sarcoma Treatment

What this Trial Is About

Researchers are evaluating two neoadjuvant hypofractionated radiotherapy regimens followed by surgical removal for treating soft tissue sarcomas located in the extremities, pelvis, chest wall, or trunkabdominal wall. This study aims to determine if shorter courses of radiation therapy 5 or 15 days can provide effective local control of the cancer without increasing the risk of wound complications or local recurrence compared to the traditional 5-week radiation schedule. Participants are assigned to one of two groups by their radiation oncologist. One group receives ultra-hypofractionated radiotherapy consisting of 5 daily radiation treatments before surgery, while the other group receives moderately hypofractionated radiotherapy with 15 daily treatments before surgery. After completing radiation and surgical resection, patients are monitored regularly over at least two years to assess outcomes and side effects. During the study, patients undergo radiation therapy followed by surgery. Researchers will track local control rates of the sarcoma about two years after treatment and record complication rates using established criteria for radiation side effects and post-operative issues. Patients are followed up within three months after treatment, then every 3 to 6 months for a minimum of two years to monitor long-term effects and cancer control.

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas