Actively Recruiting
Hypofractionated WPPT With HDR Boost
Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-02-05
30
Participants Needed
1
Research Sites
567 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a phase II study of ultrahypofractionated whole pelvis proton therapy with brachytherapy boost for patients with high risk or unfavorable intermediate risk prostate with elevated risk of lymph node involvement.
CONDITIONS
Official Title
Hypofractionated WPPT With HDR Boost
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologic evidence of prostate cancer
- High risk or unfavorable intermediate risk prostate cancer as defined by specific tumor stage, Gleason Grade Group, or PSA levels
- Appropriate for whole pelvis treatment per oncologist or lymph node risk nomogram
- Candidate for definitive external beam radiotherapy with no prior radiation in the treatment area
- No inflammatory bowel disease or active collagen/vascular/connective tissue disorders
- Age 18 years or older
- ECOG performance status of 0 to 2
- May have started androgen deprivation therapy up to 3 months before radiation or up to 3 months after radiation starts
- Completed pretreatment evaluations including history and physical exam, prostate MRI, PSMA PET, and PSA level within 6 weeks prior to enrollment
- Eligible for rectal spacer procedure
- Able and willing to sign informed consent
You will not qualify if you...
- Evidence of distant metastatic disease
- History of inflammatory bowel disease or active collagen/vascular/connective tissue disorders
- Prior radiation therapy to the pelvis
- Prior or concurrent invasive second malignancy except non-melanoma skin cancer unless disease-free for at least five years
- Severe active co-morbidities that may interfere with study completion or safety
- Prior history of transurethral resection of the prostate (TURP)
- Pre-treatment International Prostate Symptom Score (IPSS) greater than 20 or on maximum alpha-blocker medications at baseline
- Use of therapeutic anticoagulation
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
P
Project Manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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