Study of Hypothyroidism Risk After TAVI Procedure in Patients Aged 70 and Older

What this Trial Is About

Aortic stenosis is a common condition as people age, especially after age 75, and can lead to serious symptoms and high mortality without treatment. This research investigates hypothyroidism occurring after trans-catheter aortic valve replacement TAVI, a less invasive alternative to surgery for high-risk or frail elderly patients. The study aims to prospectively identify how often hypothyroidism develops after TAVI and what factors like thyroid disease or medications might predict it, as well as how hypothyroidism affects patients overall health and function. The study involves elderly patients undergoing the TAVI procedure, which improves heart function by replacing the aortic valve through a catheter. Before and after TAVI, patients receive diagnostic tests including blood samples to assess thyroid function and iodine exposure. The study monitors thyroid hormone levels and antibodies at baseline and up to 12 weeks post-procedure to detect hypothyroidism and its causes. Researchers also evaluate the impact of hypothyroidism on patients dependence, cognitive function, mood, mobility, and daily living during the first month after TAVI. Participants will have blood and urine tests at specific intervals to measure thyroid hormones and iodine levels, along with ultrasound imaging of the thyroid. Assessments of physical and mental health are performed before TAVI and one month after to understand hypothyroidisms effects. The main outcomes include how many patients develop hypothyroidism and the role of underlying thyroid conditions or iodine exposure. The study follows patients over several weeks to gather detailed information on thyroid health and related functional changes after TAVI.

Hypothyroidism After the TAVI Procedure in Elderly Patients