Actively Recruiting
HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
Led by Vilnius University · Updated on 2023-08-14
262
Participants Needed
4
Research Sites
277 weeks
Total Duration
On this page
Sponsors
V
Vilnius University
Lead Sponsor
V
Vilnius University Hospital Santaros Klinikos
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.
CONDITIONS
Official Title
HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure
- Acute hypoxemic respiratory failure defined by respiratory rate 6525 breaths/min
- PaO2/FiO2 ratio 64300 mm Hg or SpO2/FiO2 ratio <235 while spontaneously breathing under standard oxygen with flow rate of at least 10 L/min, high flow oxygen therapy, or non-invasive ventilation
- Informed consent obtained
You will not qualify if you...
- Impaired consciousness with Glasgow coma score <14
- Inability to cooperate or intolerance to prone position
- Immediate need for endotracheal intubation
- Presence of do-not-intubate order at time of inclusion
- Contraindication to high flow oxygen therapy or non-invasive ventilation
- PaCO2 above 50 mm Hg and pH <7.3
- Vasopressor dose >0.3 bcg/kg/min norepinephrine-equivalent to maintain systolic blood pressure >90 mmHg
- Positive test for Covid-19
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
Kaunas, Lithuania
Not Yet Recruiting
2
Republican Vilnius University Hospital
Vilnius, Lithuania, 04130
Not Yet Recruiting
3
Vilnius University Hospital Santaros Klinikos
Vilnius, Lithuania
Actively Recruiting
4
Barking, Havering and Redbridge University Hospitals NHS Trust
London, United Kingdom
Not Yet Recruiting
Research Team
T
Tomas Jovaisa, Prof
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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