Actively Recruiting
Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
Led by University Hospitals Cleveland Medical Center · Updated on 2025-07-30
80
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies. There are three main ways to treat this: waiting for it to pass naturally, using medication, or having surgery. Surgery is the most effective, working 99% of the time, compared to waiting (80% effective in 8 weeks) and medication (71-84% effective). Currently, surgery involves dilation of the cervix and curettage (removal of pregnancy tissue) with suction provided either from a manual hand-held pump or a machine. For the purposes of this study, a manual vacuum aspirator (or hand-held pump) will be used with ultrasound guidance. There is also another method called hysteroscopic resection, where the doctor uses a special camera to directly see and remove any pregnancy tissue from your uterus. Patients often want the quickest way to resolve the pregnancy loss, and physicians are unsure which surgical method is the best. It's also unclear if one type of surgery causes less scar tissue inside the uterus, affects the ability to test the tissue for genetic issues, or impacts how soon a patient can start fertility treatments again. This study aims to find out if hysteroscopic resection provides faster resolution and creates less scar tissue compared to the manual vacuum aspiration.
CONDITIONS
Official Title
Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult women age 18-55
- Ultrasound diagnosis of early pregnancy loss
- Less than 9 weeks gestational age by ultrasound
- Singleton non-viable pregnancy
- Willingness to follow all study procedures and availability for study duration
- Signed and dated informed consent given
- Chose a surgical method for fetal loss management
You will not qualify if you...
- Pregnancy of unknown location
- Current viable pregnancy
- Prior medical treatment for this early pregnancy loss
- Contraindications to surgery
- Active infection such as fever, chills, or uterine tenderness
- Pre-existing blood clotting disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
K
Kylie Phillips
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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