Actively Recruiting

Phase Not Applicable
Age: 18Years - 55Years
FEMALE
NCT07088510

Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy

Led by University Hospitals Cleveland Medical Center · Updated on 2025-07-30

80

Participants Needed

1

Research Sites

160 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies. There are three main ways to treat this: waiting for it to pass naturally, using medication, or having surgery. Surgery is the most effective, working 99% of the time, compared to waiting (80% effective in 8 weeks) and medication (71-84% effective). Currently, surgery involves dilation of the cervix and curettage (removal of pregnancy tissue) with suction provided either from a manual hand-held pump or a machine. For the purposes of this study, a manual vacuum aspirator (or hand-held pump) will be used with ultrasound guidance. There is also another method called hysteroscopic resection, where the doctor uses a special camera to directly see and remove any pregnancy tissue from your uterus. Patients often want the quickest way to resolve the pregnancy loss, and physicians are unsure which surgical method is the best. It's also unclear if one type of surgery causes less scar tissue inside the uterus, affects the ability to test the tissue for genetic issues, or impacts how soon a patient can start fertility treatments again. This study aims to find out if hysteroscopic resection provides faster resolution and creates less scar tissue compared to the manual vacuum aspiration.

CONDITIONS

Official Title

Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy

Who Can Participate

Age: 18Years - 55Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult women age 18-55
  • Ultrasound diagnosis of early pregnancy loss
  • Less than 9 weeks gestational age by ultrasound
  • Singleton non-viable pregnancy
  • Willingness to follow all study procedures and availability for study duration
  • Signed and dated informed consent given
  • Chose a surgical method for fetal loss management
Not Eligible

You will not qualify if you...

  • Pregnancy of unknown location
  • Current viable pregnancy
  • Prior medical treatment for this early pregnancy loss
  • Contraindications to surgery
  • Active infection such as fever, chills, or uterine tenderness
  • Pre-existing blood clotting disorders

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University Hospitals

Cleveland, Ohio, United States, 44106

Actively Recruiting

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Research Team

K

Kylie Phillips

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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