Actively Recruiting
iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
Led by University of Illinois at Chicago · Updated on 2026-01-30
360
Participants Needed
2
Research Sites
208 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Chicago
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first intervention involves the use of multiple consumer mHealth apps and sensor devices (MyApps) for heart failure self-care (maintenance, monitoring, and management). The second intervention is a program of tailored text messages (Text4HF) targeting modifiable behavioral factors associated with heart failure self-care non-adherence. The main questions this study aims to answer are: 1. Can the use of consumer mHealth apps and devices (MyApps) improve heart failure self-care and reduce days lost due to cardiovascular hospitalization or death for any cause? 2. Can a program of individually tailored text messages (Text4HF) improve heart failure self-care and reduce the days lost due to cardiovascular hospitalization or death for any cause? 3. Can MyApps and Text4HF combined lead to greater improvements in heart failure self-care and days lost due to cardiovascular hospitalization or death for any cause
CONDITIONS
Official Title
iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Stage C Heart Failure
- 18 years of age or older
- Transthoracic Echocardiogram or Cardiac MRI performed in the last 3 years with LVEF results available
- Actively treated with oral loop diuretics for chronic heart failure
- Hospitalization due to acute decompensated heart failure within 24 months before randomization and/or insufficient self-care per SCHFI assessment
- Ability to speak and read English
You will not qualify if you...
- Implanted ventricular assist device
- High urgent status for heart transplantation
- Acute coronary syndrome within 7 days before randomization
- Revascularization and/or CRT implantation within 28 days before randomization
- Planned revascularization, transcatheter aortic valve implantation, MitraClip, and/or CRT implantation within 3 months after randomization
- End-stage heart failure (hospice candidate)
- Discharge to a setting other than home
- Having a home nurse or inability to take care of self (eat, dress, walk, bathe, take medications, or use the toilet)
- Chronic renal insufficiency requiring hemodialysis or estimated Glomerular Filtration Rate less than 25 mL
- Active cancer under treatment (e.g., radiation, immunotherapy)
- Any disease reducing life expectancy to less than 1 year
- Cognitive impairment (e.g., dementia, Parkinson's disease, Alzheimer's disease, MoCA <18, impaired self-determination, or inability to communicate)
- Major physical impairment (e.g., inability to walk, wheelchair bound)
- Unwillingness to use study equipment
- Active substance abuse
- Currently pregnant, less than 3 months postpartum, or planning pregnancy during the study
- Participation in other treatment studies or remote patient management programs
- Participation in the iCardia4HF pilot trial conducted before this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
2
University of Illinois Hospital & Health Sciences System
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
S
Spyros Kitsiou, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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