Actively Recruiting
iCorMicA - Stratified Medicine in Angina
Led by NHS Greater Glasgow and Clyde · Updated on 2026-04-09
1500
Participants Needed
39
Research Sites
521 weeks
Total Duration
On this page
Sponsors
N
NHS Greater Glasgow and Clyde
Lead Sponsor
U
University of Glasgow
Collaborating Sponsor
AI-Summary
What this Trial Is About
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
CONDITIONS
Official Title
iCorMicA - Stratified Medicine in Angina
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Clinical plan for invasive coronary angiography
- Symptoms of angina (typical or atypical) as identified by Rose or Seattle Angina questionnaires
- Ability to comply with study procedures
- Ability to provide informed consent
You will not qualify if you...
- Non-coronary primary reason for invasive angiography (e.g., valve disease, heart failure)
- History of coronary artery bypass surgery
- Presence of obstructive disease in a main coronary artery (diameter >2.5 mm), defined as coronary stenosis >50% and/or fractional flow reserve (FFR) ≤ 0.80
- Logistical reasons preventing participation (these patients may join a follow-up registry)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 39 locations
1
Mater Private Hsopital
Cork, Ireland
Completed
2
Mater Private Hospital
Dublin, Ireland
Completed
3
Radboud University Medical Centre
Nijmegen, Netherlands
Actively Recruiting
4
5th Military Hospital
Krakow, Poland
Actively Recruiting
5
Golden Jubilee National Hospital
Clydebank, Scotland, United Kingdom, G814DY
Actively Recruiting
6
Aberdeen Royal Hospital
Aberdeen, United Kingdom
Completed
7
William Harvey Hospital
Ashford, United Kingdom
Actively Recruiting
8
Basildon University Hospital - Essex Cardiothoracic Centre
Basildon, United Kingdom
Completed
9
Bedford Hospital NHS Trust
Bedford, United Kingdom
Actively Recruiting
10
Royal Victoria Hospital
Belfast, United Kingdom
Actively Recruiting
11
Birmingham Heartlands Hospital
Birmingham, United Kingdom
Actively Recruiting
12
Royal Blackburn Teaching Hospital
Blackburn, United Kingdom
Actively Recruiting
13
Victoria Hospital
Blackpool, United Kingdom
Actively Recruiting
14
Glan Clwyd Hospital
Bodelwyddan, United Kingdom
Actively Recruiting
15
Royal Bournemouth Hospital
Bournemouth, United Kingdom
Completed
16
Royal Papworth Hospital NHS Foundation Trust
Cambridge, United Kingdom
Active, Not Recruiting
17
University Hospital of Wales
Cardiff, United Kingdom
Actively Recruiting
18
St Peter's Hospital NHS Foundation Trust
Chertsey, United Kingdom
Actively Recruiting
19
University Hospitals Coventry & Warwickshire NHS Trust
Coventry, United Kingdom
Actively Recruiting
20
University Hospital Hairmyres
East Kilbride, United Kingdom
Actively Recruiting
21
NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Not Yet Recruiting
22
Raigmore Hospital
Inverness, United Kingdom
Actively Recruiting
23
Leeds Teaching Hospital NHS Trust
Leeds, United Kingdom
Actively Recruiting
24
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
Actively Recruiting
25
Royal Free Hospital
London, United Kingdom, NW3
Actively Recruiting
26
Barts Health NHS Trust - St. Bartholomew's Hospital
London, United Kingdom
Active, Not Recruiting
27
King's College Hospital
London, United Kingdom
Actively Recruiting
28
Northwick Park Hospital
London, United Kingdom
Actively Recruiting
29
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Actively Recruiting
30
Royal Gwent Hospital
Newport, United Kingdom
Actively Recruiting
31
Nottingham University Hospitals NHS TRUST
Nottingham, United Kingdom
Actively Recruiting
32
Queen Alexandra Hospital
Portsmouth, United Kingdom
Actively Recruiting
33
Northern General Hospital
Sheffield, United Kingdom
Actively Recruiting
34
University Hospital Southampton
Southampton, United Kingdom
Actively Recruiting
35
South Tyneside and Sunderland NHS Foundation Trust
Sunderland, United Kingdom
Actively Recruiting
36
Morriston Hospital
Swansea, United Kingdom
Actively Recruiting
37
Pinderfields General Hospital
Wakefield, United Kingdom
Actively Recruiting
38
Watford general Hospital
Watford, United Kingdom
Completed
39
New Cross Hospital
Wolverhampton, United Kingdom
Actively Recruiting
Research Team
C
Colin Berry, MBChB, PhD
CONTACT
D
Daniel Ang, MBChB
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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