Study to Identify Blood and Tissue Biomarkers in Patients with Vascular Anomalies to Improve Diagnosis and Treatment

What this Trial Is About

Researchers are studying vascular anomalies, which are rare but can be life-threatening and severely impact children and their families. This study aims to identify non-invasive blood biomarkers that can improve diagnosis, monitoring, and treatment of these conditions. Since tissue biopsies can worsen the disease, finding specific blood markers is important to help guide new therapies. The study collects blood samples serum and plasma and tissue from participants undergoing surgical removal of vascular anomalies or sclerotherapy. Blood and tissue samples stored in a tissue bank will also be used. Researchers will measure angiogenic factors in blood samples at the start and during therapy. Tissue and blood collected will help identify where biomarkers originate and explore disease pathways for potential new treatments. Participants will have blood drawn during standard care or procedures, with consent. Tissue removed during surgery or blood taken before sclerotherapy will be used for analysis. Researchers will monitor biomarkers every two years to correlate them with diagnosis, disease severity, and response to treatment. The study involves ongoing observation and sample collection to better understand vascular anomalies and improve care.

Identification of Biomarkers for Patients with Vascular Anomalies