Actively Recruiting
Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis
Led by Istituto Ortopedico Rizzoli · Updated on 2025-01-27
30
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the present study is to evaluate the expression of a large panel of microRNAs, already known and validated in other ortopedic pathologies and bone metabolism, in the plasma of Adolescent Idiopathic Scoliosis (AIS) patients. The deregulated microRNAs identified will be then validated and computational analyzes will determine their potential involvement in the metabolism of bone and/or cartilage tissue in order to correlate the results obtained with the clinical data of the AIS patients. The investigators aimed to develop a microRNAs panel to further validate in a larger population of AIS patients in order to produce a device for the diagnosis and prognosis of Molecular-based AIS.
CONDITIONS
Official Title
Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 11 and 17 years
- Diagnosis of idiopathic scoliosis with a Cobb angle greater than 10 degrees
- Minimum follow-up of two years
- Clinical data and radiological tests available
- No surgical treatment prior to enrollment
- Healthy subjects aged 11 to 17 years without orthopedic or oncological diseases (controls)
You will not qualify if you...
- Severe cognitive impairment or psychiatric disorders
- Scoliosis due to secondary causes
- Women of childbearing age who are pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dipartimento Rizzoli-Sicilia
Bagheria, Italy, 90011
Actively Recruiting
Research Team
G
Gianluca Giavaresi, MD
CONTACT
L
Lavinia Raimondi, BSc PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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