Genetic Study to Identify Variants Associated with Lichen Sclerosus in Families

What this Trial Is About

Researchers are investigating genetic factors linked to Lichen Sclerosus, a skin condition affecting the genital area that can cause itching, pain, and difficulty with daily activities. This condition may be more common in white populations and can involve the skin outside the genital area in some cases. The study focuses on families with members affected by Lichen Sclerosus to understand underlying genetic causes and potentially discover new genes related to the disease. This observational study will collect genome sequencing data from families where some members have Lichen Sclerosus and others do not. By comparing genetic differences within these families, researchers aim to identify new genetic variants associated with the condition. The study is not interventional and does not involve treatments but focuses on genetic analysis over a five-year period. Participants will be family members affected by or related to someone with Lichen Sclerosus. Researchers will analyze genetic samples to identify potential disease-related genes. The main measure is the identification of novel genes linked to Lichen Sclerosus during the study. Participants will be followed for up to five years, contributing genetic data to help advance understanding of the disease and its hereditary factors.

Identification of Genetic Variants Associated With Lichen Sclerosus