Genetic Study to Identify Variants Linked to Sudden Unexpected Infant Death and Sudden Infant Death Syndrome

What this Trial Is About

Researchers are conducting a multicenter genetic study to identify new genes or genetic variants linked to sudden infant death syndrome SIDS by using whole-genome sequencing of family trios. This study is part of a larger project called BIOMINRISK, which also explores neurobiology and radio-anatomical aspects. It includes both retrospective and prospective cases of sudden unexpected infant death SUDI registered in the French national registry. The study focuses on sudden unexpected infant death cases and their biological parents, forming trios for genetic analysis. Whole genome sequencing will be performed on the infant who died from SIDS and both parents to detect pathogenic variants, particularly those not inherited from the parents de novo variants. The sequencing data will be analyzed to better understand genetic factors contributing to SIDS. Participants will be involved through blood sample collection and inclusion in a biocollection. The research team will analyze genetic data to identify specific variants and potential correlations between genotypes and phenotypes over a period of up to 38 months. This observational study does not involve treatment, but closely monitors genetic markers associated with SIDS for research purposes.

Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome