Actively Recruiting
Led by Nantes University Hospital · Updated on 2026-05-08
650
Participants Needed
15
Research Sites
60 weeks
Total Duration
N
Nantes University Hospital
Lead Sponsor
A
AXA Assurances VIE Mutuelle
Collaborating Sponsor
Researchers are conducting a multicenter genetic study to find new gene variants linked to sudden infant death syndrome (SIDS) by analyzing the whole genomes of affected infants and their parents. This project is part of a larger study called BIOMINRISK, which also explores neurobiology and radio-anatomical aspects. The study includes cases of sudden unexpected death in infants (SUDI) both retrospectively from a national registry and prospectively through referral centers. The study involves whole genome sequencing of infants diagnosed with SIDS and their biological parents to identify harmful genetic variants. Researchers analyze the data using a trio approach to detect new genetic changes present in the infant but absent from both parents. This genetic analysis helps explore possible causes of SIDS by examining all coding and non-coding parts of the genome. Participants include infants who died suddenly and unexpectedly before age 2 and their biological parents. The study collects blood samples and genetic data, with consent from parents. Researchers will monitor genetic findings over about 38 months, looking for new genetic variants, copy number changes, and links between genetic profiles and physical traits. The study is observational and does not involve treatment, but aims to improve understanding of SIDS risks.
CONDITIONS
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies depending on timing of post-mortem results
Participants who are cases of sudden unexpected infant death undergo post-mortem examinations to identify sudden infant death syndrome (SIDS) among these cases.
1 visit (in-person)
Duration - Up to 38 months
Whole genome sequencing samples are collected from identified SIDS cases and their biological parents to identify genetic variants.
1 to 2 visits depending on sample availability
Duration - Up to 38 months
Genetic data generated from sequencing is analyzed over time to identify pathogenic allelic variants and new genotype-phenotype correlations.
Additional assessments may occur depending on cohort assignment
Total: 15 locations
1
Nantes University Hospital
Nantes, Loire-Atlantique, France, 44093
Actively Recruiting
2
CHU Amiens
Amiens, France
Actively Recruiting
3
CHU Angers
Angers, France
Actively Recruiting
4
CHU Besançon
Besançon, France
Actively Recruiting
5
APHP - Hôpital Jean Verdier
Bondy, France
Actively Recruiting
6
CHU Brest
Brest, France
Actively Recruiting
7
APHP - Hôpital Antoine Béclère
Clamart, France
Actively Recruiting
8
CHU Grenoble
Grenoble, France
Actively Recruiting
9
HCL
Lyon, France
Actively Recruiting
10
AP-HM
Marseille, France
Not Yet Recruiting
11
CHU Montpellier
Montpellier, France
Actively Recruiting
12
CHRU Nancy
Nancy, France
Actively Recruiting
13
CHU Rouen
Rouen, France
Actively Recruiting
14
CHU Saint Etienne
Saint-Etienne, France
Actively Recruiting
15
CHU Toulouse
Toulouse, France
Actively Recruiting
F
Fleur Lorton
A
Alban-Elouen BARUTEAU
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Mathilde Ducloyer, Alban-Elouen Baruteau, Patricia Franco...
https://pubmed.ncbi.nlm.nih.gov/40738637