Actively Recruiting
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Led by Assistance Publique Hopitaux De Marseille · Updated on 2026-02-12
25
Participants Needed
1
Research Sites
79 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide. The aim of this trial is to identify new prognostic markers for the progression of sepsis to septic shock, by comparing epigenetic markers between patients who have or have not developed severe forms of sepsis. The main objective of this preliminary study is to identify prognostic markers for the progression of sepsis to septic shock, i.e. to compare targeted markers between subjects with sepsis who progress to septic shock versus subjects with sepsis who do not progress to septic shock.
CONDITIONS
Official Title
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients
- Patients between 45 and 75 years of age
- Patients undergoing major esophageal or digestive carcinological surgery
- Patients with post-operative gram-negative bacterial sepsis (proven or suspected in the context of organ failure)
You will not qualify if you...
- Patients under 45 and aged 76 and over
- Female patients
- Non-carcinological or minor surgery
- Non-esophageal or non-digestive surgery
- Gram-positive bacterial or fungal infections without associated gram-negative bacteria
- Patients with hematological cancer
- Immunocompromised patients
- Septic surgery (surgical site infection)
- Patients opposing data collection and analysis within the study regulations
- Patients under guardianship or curatorship
- Patients not affiliated with a social security system or equivalent in France
- Patients deprived of their liberty
AI-Screening
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Trial Site Locations
Total: 1 location
1
Service Anesthésie Réanimation - Hôpital Nord - Assistance Publique Hôpitaux de Marseille
Marseille, Bouches du Rhône, France, 13015
Actively Recruiting
Research Team
M
Marc LEONE, MD PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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