Actively Recruiting
Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma
Led by St. Jude Children's Research Hospital · Updated on 2026-05-01
850
Participants Needed
3
Research Sites
748 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to provide sufficient therapy during the time a patients' B-cell Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy) risk category is being determined. The term "risk" refers to the chance of the ALL or LLy coming back after treatment. Primary Objectives * To provide sufficient therapy to enable testing of newly diagnosed acute lymphoblastic leukemia/lymphoma and mixed phenotype acute leukemia/lymphoma tumor samples to determine eligibility and appropriate risk stratification for SJALL therapeutic studies. * To develop a central database of genomic and clinical findings. Secondary Objectives * To assess event free and overall survival data of patients enrolled on this study.
CONDITIONS
Official Title
Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 1 and 18.99 years
- Diagnosis of acute lymphoblastic leukemia (ALL) with at least 25% bone marrow blasts or definitive evidence of ALL in peripheral blood if bone marrow sample unavailable
- Diagnosis of lymphoblastic lymphoma (LLy) with immunophenotypic evidence of lymphoblastic cells, less than 25% bone marrow blasts, and fewer than 1,000 circulating blasts per microliter
- Diagnosis of mixed phenotype acute leukemia (MPAL) with or without 25% bone marrow involvement, including leukemia or lymphoma forms
You will not qualify if you...
- Pregnancy or breastfeeding
- Prior cancer treatment except for up to one dose of intrathecal chemotherapy, one dose of vincristine, or emergency radiotherapy for organ-compromising masses
- Current ineligibility for available SJALL therapeutic studies due to prohibited therapy, lack of appropriate study, enrollment in competing trial, or similar reasons
- Inability or unwillingness to provide written informed consent by participant or legal guardian
- Presence of major pre-existing disorders such as ataxia telangiectasia, Fanconi anemia, or Charcot Marie Tooth disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Rady Children's Hospital
San Diego, California, United States, 92123
Actively Recruiting
2
Saint Francis Children's Hospital
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
3
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
S
Seth E. Karol, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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