Actively Recruiting
Identification of New Candidate Genes for Hereditary Predisposition to Uveal Melanoma
Led by Centre Jean Perrin · Updated on 2026-03-19
50
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
Sponsors
C
Centre Jean Perrin
Lead Sponsor
A
Association Nationale des Patients atteints de cancers de l'oeil (A.N.P.A.C.O.)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Only 20% of familial uveal melanomas are explained by a hereditary predisposition, implying the presence of as yet unknown hereditary predispositions. This hypothesis is reinforced by epidemiological studies revealing an excess risk of prostate cancer, thyroid cancer and leukemia in patients who have developed uveal melanoma, even though these cancers are not part of the tumor spectrum of known hereditary predispositions to uveal melanoma (BAP1, MBD4). The identification of new candidate genes, once validated, would enable us to offer these families appropriate surveillance.
CONDITIONS
Official Title
Identification of New Candidate Genes for Hereditary Predisposition to Uveal Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient with a personal history of uveal melanoma (newly diagnosed, under treatment or in follow-up)
- Enrolled in or benefiting from a social security scheme
You will not qualify if you...
- Causal pathogenic variation identified in BAP1 or MBD4
- Patient does not consent to constitutional genetic analysis for diagnostic purposes
- Patient not consenting to a constitutional genetic analysis for research purposes
- Pregnant and breast-feeding women
- Patients under guardianship or trusteeship
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Jean PERRIN
Clermont-Ferrand, Puy-de-Dôme, France, 63011
Actively Recruiting
Research Team
A
Angeline GINZAC COUVÉ
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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