Actively Recruiting
Identification of Plasma Biomarkers for Early Diagnosis of Transplant-associated Thrombotic Microangiopathy
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2025-08-06
500
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about plasma biomarkers of diagnosed transplant-associated thrombotic microangiopathy (TA-TMA) in patients undergoing transplantation. The main questions it aims to answer are: whether there are molecules that can accurately diagnose and predict TA-TMA; whether the current biomarkers related to TA-TMA can well predict the occurrence and survival of TA-TMA in adult patients with malignant hematopoietic diseases, for example, acute leukemia. Participants will receive laboratory tests of peripheral blood and urine specimens related to TA-TMA at regular times after transplantation.
CONDITIONS
Official Title
Identification of Plasma Biomarkers for Early Diagnosis of Transplant-associated Thrombotic Microangiopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of a hematologic disease (e.g., leukemia, myelodysplastic syndromes, lymphoma) confirmed by histology or appropriate diagnostic methods
- Undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT)
- Age 14 years or older
- Signed informed consent before study start, either by patient, immediate family member, or legal guardian if needed
You will not qualify if you...
- Missing or lost follow-up of key clinical data
- Failure to collect plasma samples at specific time points after transplantation
- Plasma samples collected after the onset date of thrombotic microangiopathy (TMA)
- TMA occurrence later than 180 days after transplantation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Tianjin, China
Actively Recruiting
Research Team
W
Wenbin Cao
CONTACT
E
Erlie Jiang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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