Study to Develop an Ultrasound Score for Measuring Pancreatic Fat and Its Link to Beta-Cell Function and Metabolic Health Understanding Pancreatic Fats Role in Type 2 Diabetes and Metabolic Syndrome

What this Trial Is About

Researchers are evaluating the connection between pancreatic fat buildup pancreatic steatosis and metabolic health, focusing on conditions like type 2 diabetes and metabolic syndrome. The study aims to develop an ultrasound elastography score to measure pancreatic steatosis and examine its relationship with beta-cell function and factors linked to type 2 diabetes development. Additionally, participants will be classified into risk groups for type 2 diabetes based on their metabolic profiles and pancreatic fat levels. The study involves 100 participants aged 18 to 80 who are undergoing endoscopic ultrasound for clinical reasons unrelated to pancreatic tumors, cystic fibrosis, or insulin-treated diabetes. During the study visit, medical history and physical measurements such as BMI, waist circumference, and blood pressure will be collected. Participants will also undergo glucose tolerance testing and blood work, including C-peptide measurement at five time points during a standard oral glucose tolerance test. Participants will be involved for a total of 24 months, including enrollment. Assessments include a single day of measuring the degree of pancreatic steatosis and evaluating metabolic and functional parameters. The study does not involve drugs or devices but seeks to better understand how pancreatic fat relates to metabolic health and type 2 diabetes risk, potentially improving future prevention and management strategies.

Identification of a Score for the Assessment of Intrapancreatic Fat