Actively Recruiting
IDENTIFY Study: Natural History of Maternal Neoplasia
Led by National Human Genome Research Institute (NHGRI) · Updated on 2026-03-03
365
Participants Needed
1
Research Sites
488 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Pregnant women can get a DNA analysis of their blood. The test tells a woman and her doctor about the DNA of her unborn baby. But some women get test results that are abnormal or not reportable. Researchers want to learn more about the relationship between these test results and cancer. Objective: To better understand prenatal DNA test results and how they can predict cancer, if present, in pregnant women. Eligibility: Women 18 and older who got prenatal DNA test results that were abnormal or not reportable and suggested the abnormality was in the woman and not her baby. Design: Potential participants will be screened by phone or in person. They will talk about their medical history and send copies of their medical records. Eligible participants will have a physical exam and medical history. They will give blood and stool samples. They may have a Pap smear. They will talk to a specialist about the test results they got when they were pregnant. Participants will have magnetic resonance imaging (MRI). They will lie on a table that slides in and out of a metal tube, taking pictures. Participants will complete a paper or electronic survey. It will assess their emotional well-being. Participants will get a list of any possible diagnoses and treatment options. Participants may be followed for up to 5 years. They may give blood samples and copies of their medical records. This can be done without traveling to the NIH. In some cases, people might come back to the NIH in one year to see if anything has changed.
CONDITIONS
Official Title
IDENTIFY Study: Natural History of Maternal Neoplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older
- Pregnancy with noninvasive prenatal testing (NIPT) showing unusual or non-reportable results suggesting maternal DNA abnormalities
- Normal-appearing fetus on ultrasound and/or normal fetal or neonatal genetic testing
- Enrollment during pregnancy or up to two years postpartum
- Ability to travel to NIH
- Ability and willingness to sign informed consent
You will not qualify if you...
- NIPT results previously linked to higher risk of blood cancers, such as Trisomy 8, 20delq, or 5delq
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
A
Amy E Turriff
CONTACT
B
Benjamin D Solomon, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here