Actively Recruiting
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
Led by National Taiwan University Hospital · Updated on 2025-06-06
480
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC). Selecting the appropriate flow rate when initiating HFNC oxygen therapy is both crucial and challenging for clinicians, as the physiological benefits of HFNC depend significantly on the flow rate. To date, there are no guidelines or consensus on flow-rate setting and weaning for HFNC oxygen therapy. The investigators hypothesized that physiological marker-guided flow setting using peak tidal inspiratory flow (PTIF) or PaO₂/FiO₂ ratios lead to better extubation outcomes as compared to empirical flow setting of 40 L/min or 60 L/min. Participants will be randomly assigned to one of four study groups with different flow setting strategies summarized as follows: (1) Setting flow at 40 L/min, (2) Setting flow at 5 L/min above the peak tidal inspiratory flow, up to a maximum of 60 L/min. (3) Setting flow according to P/F ratio prior to extubation. Flow will be set at 60, 50 40 L/min if P/F ratio \<250 mmHg, 250-300 mmHg and \>300 mmHg, respectively. (4) Setting flow at 60 L/min.
CONDITIONS
Official Title
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intubated and receiving mechanical ventilation for more than 24 hours
- Ready for planned extubation after passing a spontaneous breathing trial
- PaO2/FiO2 ratio less than 350 mmHg on the day of extubation
You will not qualify if you...
- Younger than 18 years
- Have a do-not-reintubate order
- Pregnant women
- Have tracheostomies
- Unable to use high-flow nasal cannula
- Planning to use preventive noninvasive ventilation after extubation
- Life expectancy less than one month
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
S
Sheng-Yuan Ruan, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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