Actively Recruiting
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Led by Mayo Clinic · Updated on 2026-04-29
200
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.
CONDITIONS
Official Title
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years and older
- Ability to provide written informed consent
- Adequate cognitive and language abilities to understand and complete study tasks, including clinical assessments and fNIRS procedures
- Confirmed clinical diagnosis of major depressive disorder, bipolar disorder, or mild cognitive impairment (MCI)
- Stable psychiatric or cognitive condition, without acute episodes requiring immediate intervention
- Healthy controls with no past or current psychiatric or cognitive disorder
- Diagnosis of major depressive disorder confirmed through clinical evaluation, without history of bipolar disorder or psychotic symptoms
- Diagnosis of bipolar disorder I or II confirmed through clinical evaluation
- Diagnosis of mild cognitive impairment supported by neuropsychological testing and/or MRI or PET scan data, without history of major psychiatric disorders such as major depression, bipolar disorder, or schizophrenia
You will not qualify if you...
- Active primary psychotic or substance use disorders (except nicotine dependence) within the past year
- Severe or unstable medical conditions interfering with participation or data collection
- Active neurological conditions like seizure disorder, traumatic brain injury, or stroke affecting cognition or brain imaging
- Inability to comply with study procedures including cognitive testing and fNIRS assessment
- Pregnancy
- Healthy controls with any past or current psychiatric or cognitive disorder
- Major depressive disorder patients with diagnosis of bipolar disorder or schizophrenia
- Brain stimulation therapy within the past 3 months for major depressive disorder patients
- Bipolar disorder patients diagnosed with schizophrenia or schizoaffective disorder
- Mild cognitive impairment patients diagnosed with dementia
- Significant cognitive impairment preventing understanding or completion of study tasks in mild cognitive impairment patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
S
Sarah M. Williams
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here