Actively Recruiting
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach
Led by The University of Texas Health Science Center, Houston · Updated on 2025-03-19
200
Participants Needed
1
Research Sites
587 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.
CONDITIONS
Official Title
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be between 18-80 years old
- Male or female
- Must be right handed
- Must be able to sit unaccompanied for long periods of time with little body movement
- Must be illicit drug free at time of scanning as appropriate (negative urine drug screen)
- Must be either healthy or have a diagnosis of a neuropsychiatric syndrome such as mood disorder, chronic pain syndrome, dementias, traumatic brain injury, or substance/alcohol use disorder
- Healthy control volunteers must be medication free for at least 14 days
- Illicit drug free at time of scanning (verified by negative urine drug screen)
You will not qualify if you...
- Must not be a smoker
- Females must not be pregnant or nursing
- Must not suffer from claustrophobia
- Must not meet exclusion criteria for MRI scanning (e.g., presence of non-fixed magnetisable objects)
- Must not be a PBR-28 low affinity binder (or using the [11C]ER176 radiotracer study)
- Healthy control volunteers must not have ongoing, chronic, or relapsing/remitting medical, psychiatric, or neurological illness as determined by history, medical record, or examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
BBSB at UTHealth
Houston, Texas, United States, 77054
Actively Recruiting
Research Team
A
Alan Prossin, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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