Actively Recruiting
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
Led by The University of Texas Health Science Center, Houston · Updated on 2025-05-08
75
Participants Needed
1
Research Sites
190 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological indices of reward sensitivity and motivated attention in adults with cocaine use disorder.
CONDITIONS
Official Title
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Non-treatment-seeking adults
- Meet DSM-5 criteria for current cocaine use disorder of at least moderate severity (4 or more symptoms)
- Have at least one positive urine test for Benzoylecgonine (300 ng/mL or higher) during intake
- Able to understand and provide written informed consent
- Able to provide verifiable contact information for at least two persons, including full legal name, email address, local mailing address, and phone numbers as applicable
You will not qualify if you...
- Current moderate or severe substance use disorder other than cocaine, marijuana, or nicotine
- Any medical, neurological, psychiatric, or physical condition that may interfere with study completion or safety as judged by the principal investigator
- Current or recent suicidal or homicidal ideation or behavior as assessed by clinical interviews and safety scales
- Medical implants contraindicating TMS (e.g., aneurysm clips, pacemakers, brain stimulators, cochlear implants, magnetic implants, bullet fragments) within 30 cm of the coil
- History of brain surgery or intracranial lesions or conditions associated with increased intracranial pressure
- Symptoms such as headaches more than 15 days per month or vision loss within 30 days before enrollment
- Moderate to severe heart disease or history of stroke
- Taking antidepressant or antipsychotic medications at unsafe doses or medications that increase seizure risk within one week prior to enrollment
- Conditions of probation or parole requiring drug use reports
- Personal or family history of epilepsy or seizure disorder
- Serious head injury with loss of consciousness
- Impending incarceration
- Pregnant or nursing women
- Inability to read, write, or speak English
- For participants aged 18 to 21, any risk factor for neurocardiogenic syncope
- Hair styles incompatible with EEG nets
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
H
Heather Webber, PhD
CONTACT
J
Jessica Vincent
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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