Actively Recruiting
Identifying Local Field Potential Biomarkers for Obsessive-compulsive Disorder Treatment With Deep Brain Stimulation
Led by West China Hospital · Updated on 2024-08-07
16
Participants Needed
4
Research Sites
121 weeks
Total Duration
On this page
Sponsors
W
West China Hospital
Lead Sponsor
B
Beijing Pins Medical Co., Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
Obsessive-compulsive disorder (OCD) is a complex and severe mental illness characterized by multiple symptoms and is considered a leading cause of non-fatal health loss. However, nearly 20% of patients do not respond to standard pharmacological or psychological treatments. Currently, we lack objective brain-based biomarkers. To address this issue, we used a novel device for electrophysiology recording and applied deep brain stimulation (DBS) to 16 OCD patients. In this study, we aim to use long-term invasive neural signal collection and machine learning techniques to reveal the complex relationship between these signals and OCD symptoms. By applying advanced machine learning algorithms, our goal is to establish highly accurate prediction models to identify biomarkers associated with the occurrence and progression of OCD. The research will focus on the spatiotemporal features of neural signals and build personalized OCD decoding models based on individual differences through the integration and analysis of large-scale data. By delving into the information contained in neural signals, we hope to provide academic and practical innovations for the development of personalized treatment approaches for OCD.
CONDITIONS
Official Title
Identifying Local Field Potential Biomarkers for Obsessive-compulsive Disorder Treatment With Deep Brain Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with OCD according to the criteria in the DSM-5.
- Age between 18 and 65 years.
- Duration of illness of more than 3 years.
- Ineffectiveness of systematic treatment with three types of serotonin reuptake inhibitors (including clomipramine) and augmentation agents, with no improvement after continuous high-dose serotonin reuptake inhibitor treatment for more than 12 weeks, or the occurrence of severe adverse drug reactions during treatment.
- Ineffectiveness of CBT treatment or repeated refusal of CBT treatment.
- Y-BOCS total score of 25 or higher.
- Significant impairment in social functioning, such as inability to work or attend school, or a noticeable decline in personal life skills.
- No severe impairment in insight, and capable of signing informed consent and surgery consent forms.
You will not qualify if you...
- Presence of bipolar disorder, schizoaffective disorder, schizophrenia, or other psychotic disorders.
- Severe personality disorders.
- Severe physical illnesses or organic brain diseases.
- Diagnosis of alcohol or substance abuse and dependence according to DSM-IV criteria within one year prior to screening.
- Study participants with contraindications for surgery, such as major medical comorbidities or inability to discontinue anticoagulant medications.
- Preoperative head MRI showing significant structural abnormalities.
- Contraindications for MRI examination (excluding the DBS implant or stimulator itself).
- Pregnancy or breastfeeding.
- Study participants currently enrolled in another research study unrelated to the current study.
- Any condition that currently or in the future might endanger the safety of the study participant or prevent the successful participation in the study (including family support, medical, psychological, social, or geographical factors).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
West CHina Hospital，Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
2
The First People's hospital of Longquanyi District
Chengdu, Sichuan, China
Not Yet Recruiting
3
Zigong Fifth People's Hospital
Zigong, Sichuan, China
Actively Recruiting
4
Zigong Fourth People's Hospital
Zigong, Sichuan, China
Not Yet Recruiting
Research Team
B
Botao Xiong, M.D.
CONTACT
W
wei wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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