Actively Recruiting
Identifying Markers of Exercise Training in Heart Failure
Led by Stanford University · Updated on 2026-02-13
90
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The heart failure syndrome that occurs when the heart is too sick to properly do its job. One of the main symptoms is difficulty with exercise. One way to improve symptoms is to start patients in a 12 week exercise program called cardiac rehabilitation. Cardiac rehabilitation been shown to improve symptoms for heart failure patients. However, the investigators do not know exactly what exercise does to the molecules that make up the human body. If the investigators could answer this question, the investigators might find a whole new way to treat the symptoms of heart failure. Therefore the investigators want to know what molecules might be responsible for the benefits of exercise. The plan for this study is to measure the levels of thousands of proteins in blood samples which come from people with heart failure and see how those levels change after 12 weeks of cardiac rehabilitation, compared to the protein levels in patients whose cardiac rehabilitation is delayed until after the study period. If the investigators know the proteins that change with exercise, the investigators can then look to see if targeting these proteins with medicines can mimic the benefits of exercise. The long term goal of our work is to identify "exercise-in-a-pill" medicines that will help people with heart failure.
CONDITIONS
Official Title
Identifying Markers of Exercise Training in Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and availability for the study duration
- Male or female aged 18 to 89 years
- Diagnosis of heart failure with ejection fraction less than 40%
- Willing to participate in cardiac rehabilitation and have not done so in the last year
- Agree to follow lifestyle considerations during the study
- Able to exercise on a treadmill
You will not qualify if you...
- Unable to complete cardiopulmonary exercise testing or participate in cardiac rehabilitation
- Syncope during exercise test within last 6 months, sustained ventricular tachycardia or significant arrhythmia during exercise test
- Body mass index 38 or higher
- History of bleeding disorder or clotting abnormality
- Severe chronic obstructive pulmonary disease
- History of cancer not in remission or recent cancer treatment
- Cirrhosis
- Thyroid disease with abnormal thyroid stimulating hormone levels or unstable treatment
- Active cancer treatment or recent anti-hormonal therapy
- Chronic active or latent infections requiring ongoing treatment, including HIV and active hepatitis B or C
- Current tobacco or e-cigarette use or stopped smoking less than 6 months ago
- Pregnant, lactating, postpartum within last 12 months, or planning pregnancy within next 4 months
- Metabolic bone disease with history of fractures or current treatment (except calcium, vitamin D, estrogen)
- Diabetes treated with insulin or A1c 8.0 or higher
- Chronic kidney disease with low kidney function
- Active autoimmune disorder treatment within last 6 months
- Excessive alcohol consumption or history of binge drinking
- Night shift work in last 6 months
- Recent psychiatric hospitalization
- Musculoskeletal, neurological, or other conditions impairing participation
- Cognitive impairment affecting understanding or cooperation
- Genetic metabolic disorders affecting metabolomics
- Other medical conditions or illnesses judged by clinician to prevent participation
- Use of certain medications including anabolic steroids, growth hormones, insulin, psychiatric drugs, narcotics, chronic antimicrobials, high-potency steroids, monoclonal antibodies, immune suppressants, or others affecting study participation
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Trial Site Locations
Total: 1 location
1
Stanford Health Care
Stanford, California, United States, 94305
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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