Actively Recruiting
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
Led by Rhode Island Hospital · Updated on 2025-10-23
250
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
Sponsors
R
Rhode Island Hospital
Lead Sponsor
B
Brown University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg). The main question it aims to answer is: will patients who are randomly assigned to the high 24 mg maintenance dose, as compared to patients randomly assigned to the standard 16 mg maintenance dose, have improved retention in buprenorphine treatment (primary outcome), improved treatment response based on use of non-prescribed opioids (secondary outcome), decreased opioid cravings (secondary outcome), and decreased risk of fatal and non-fatal opioid overdose (exploratory outcome).
CONDITIONS
Official Title
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English-speaking
- Age 18 years-old or older
- Identified by the treating physician as having moderate to severe opioid use disorder (OUD)
- Initiating or continuing buprenorphine for treatment of opioid use disorder
- History of fentanyl use confirmed by positive urine drug screen at intake, recent positive urine test while on treatment, or self-reported ongoing fentanyl use
You will not qualify if you...
- Previous enrollment in the trial
- Currently incarcerated or in police custody
- Pregnant
- Living outside of Rhode Island (RI)
- Unable to provide informed consent
- Allergy to Buprenorphine
- Use of medications with potential serious interactions as judged by the treating clinician
- Participants who become incarcerated or in police custody during the study will be withdrawn
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brown University
Providence, Rhode Island, United States, 02912
Actively Recruiting
Research Team
J
Jackie Goldman
CONTACT
R
Rachel Wightman, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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