Actively Recruiting
IEEM-Heat and Heart Failure
Led by University of Texas Southwestern Medical Center · Updated on 2026-03-09
88
Participants Needed
1
Research Sites
247 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated T-shirt will also be beneficial to attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. To accomplish these objectives, individuals with congestive heart failure and otherwise healthy control individuals will be exposed to the simulated heat wave condition (hot and dry) with the following cooling modalities: A) control trial (no limb immersion or skin wetting), B) skin wetting only trial, and C) water-saturated T-shirt trial in a randomized crossover fashion. Thermoregulatory and cardiovascular responses will be evaluated throughout these simulated heat wave exposures. Primary outcomes variables will be skin and core temperatures, while secondary variables will include measures of cardiovascular stress, myocardial perfusion, heart rate, and echo-based measures of cardiac function.
CONDITIONS
Official Title
IEEM-Heat and Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy control participants must be free of significant medical problems based on history, physical exam, and normal resting ECG
- Participants must be 45 years or older
- Participants with congestive heart failure must have a diagnosis categorized as NYHA class II or III
- Participants with congestive heart failure must be 45 years or older
You will not qualify if you...
- Known heart disease or other chronic medical conditions requiring regular medical therapy such as cancer, diabetes, neurological diseases, and uncontrolled hypertension
- Current smokers or those who regularly smoked within the past 12 months
- Serious abnormalities detected on routine screening
- Participants who cannot be age and gender matched to a heart failure group individual
- Participants without confirmed NYHA class II or III heart failure diagnosis
- Presence of left bundle branch block on ECG
- Use of anticoagulant therapy
- Severe valvular or congenital heart disease
- Acute myocarditis
- NYHA Class IV heart failure
- Manifest or provokable ischemic heart disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
C
Craig Crandall, PhD
CONTACT
E
Erin Harper, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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