Actively Recruiting
IEEM- Work:Rest Cycles in Burn Survivors- Humidity
Led by University of Texas Southwestern Medical Center · Updated on 2025-08-26
70
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
T
Texas Health Resources
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how severe burn injuries affect core body temperature during cycles of work and rest in a heated environment. The study compares non-burned volunteers with those who have sustained serious burns covering 20% or more of their body surface. The goal is to understand temperature responses in these groups during heat exposure, which may help improve safety and care for burn survivors. Participants will complete up to three work:rest cycles in an environmental chamber set to no higher than 40 6C. Each cycle includes 30 minutes of exercise followed by up to 20 minutes of rest while remaining in the heated space. These cycles will be performed twice in separate visits: once in low humidity and once in high humidity conditions, with the order randomized. The study groups include non-burned individuals, those with moderate burns (20-40% of body surface area), and those with large burns (over 40%). During the visits, researchers will monitor core temperature and heart rate from the start of exercise to the end of the last rest period, about 170 minutes in total. Participants will undergo medical history reviews, physical exams, and resting ECGs to confirm health status. The study lasts until 2031, and participants will be assessed for changes in temperature and heart rate related to heat exposure and burn severity.
CONDITIONS
Brief Title
IEEM- Work:Rest Cycles in Burn Survivors- Humidity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be between 18 and 65 years old.
- Participants must be free from significant underlying medical problems based on medical history, physical exam, and normal resting electrocardiogram.
- For non-burned individuals: must not have had a serious burn injury requiring more than one night in hospital.
- For moderate burn group: must have a burn covering 20-40% of body surface area with at least 50% full-thickness burns requiring skin grafts.
- For large burn group: must have a burn covering more than 40% of body surface area with at least 50% full-thickness burns requiring skin grafts.
You will not qualify if you...
- Known heart disease or other chronic medical conditions requiring regular treatment including cancer, diabetes, neurological diseases, uncontrolled hypertension, or lung disease.
- Serious abnormalities detected on routine screening.
- Current smokers or those who regularly smoked within the past 3 years.
- Body mass index (BMI) of 31 kg/m2 or higher.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 visits over a short period
Participants perform up to three work:rest cycles in a heated environmental chamber with either low or high humidity to assess their physiological responses.
2 visits (in-person), each including up to three work:rest cycles lasting approximately 170 minutes total
Trial Site Locations
Total: 1 location
1
IEEM Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
C
Craig Crandall, PhD
E
Erin Harper, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here